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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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Nick Honhold <[log in to unmask]>
Wed, 26 Feb 2014 09:29:22 +0000
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Dear All

One reason I initially started with the idea of PPR, SGPX and 
brucellosis is that all three essentially require one successful 
immunisation in the lifetime of a typical sheep or goat in many areas. I 
thought the idea of achieving a one visit coverage would appeal to 
funding agencies, especially if brucellosis was a part of the mix. I was 
working in Turkey at the time for FAO and the vet authorities there did 
not see PPR as being important whereas SGPX and brucellosis were seen as 
worth pursuing.  Knowing that Syria seemed to have high sero-prevalences 
for PPR without reported disease, I was concerned about PPR entering 
Turkey. This is another benefit of a 3 for 1 approach in that we might 
be more able to create buffers around infected areas whereas otherwise 
there would be less incentive to act.

Diseases that require frequent vaccination (annual or every 5-6 months) 
of all animals are going to be much harder to persuade those with the 
money to support, they will rightly ask how sustainable that can be. 
That isn't to say that those disease are not important, they undoubtedly 
are, just that we may struggle to get them funded. Of course, where we 
establish a good cold chain and supply system, other vaccines can use 
that to some extent, particularly if PPR/SGPX/brucellosis is done at 
particular times of the year. Rather than lying idle, the system could 
be used for other things. And in that way, we could build in the variety 
required in different areas.

Giving different combinations of vaccines could present a risk of one or 
more not producing functional immunity. I know combined SGPX/PPR 
vaccines have been produced (but not yet widely used?) and also that 
some field use of brucellosis and SGPX vaccines together has been done. 
What other field experience of using combined PPR/SGPX/brucellosis/other 
vaccines administered at the same time, as either multivalent or 
separate vaccines, has there been to date?

Regards

Nick

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