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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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Subject:
From:
Paul Rossiter <[log in to unmask]>
Reply To:
Paul Rossiter <[log in to unmask]>
Date:
Thu, 13 Feb 2014 16:38:25 +0000
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Dear Paul,

My name is Pam Luka from the National Veterinary Research Institute,
Vom Nigeria. I agreed with other colleagues on the need for post
vaccination seromonitoring as an indicator of whether we are getting
it right or not. The cost of that maybe much but the benefits are also
going to be a kind of "post vaccination positive/negative control".

After the reported PPR outbreak and in the Karamoja region, Uganda in
2006 even thought Wanwayi et al.,1995 reported the the presence of
antibodies from repository samples collected in the 1980s. Where did
the virus go then? Perhaps it vanished into thin air or eventually
found a niche for itself and compounded with poor disease surveillance
and disease reporting it remained unreported.

Vaccination was carried out after the outbreak and we went back and
carried out post-vaccination seromonitoring in 2008-2009 and discovered
seropositivity of 55.3 %  for both sheep and goats. This was not so
good for achieving "herd immunity" but it informed us of the need to
conduct a second round of vaccination.

During the same survey, we also randomly collected oculo-nasal
swabs and buffy coat from apparently healthy animals and all the buffy
coats turned out positive by reverse transcriptase PCR. 
I assume you mean positive for PPR virus. 
Are there some participants who could comment on this result please - Moderator .
So if we are to go after the virus, we should consider collecting what kind of
samples to collected in other not to miss it.


Best regards

Luka D. Pam
Applied Mol. Biol. Div.
NVRI, Vom.
Plateau State,
Nigeria

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