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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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From:
Paul Rossiter <[log in to unmask]>
Reply To:
Paul Rossiter <[log in to unmask]>
Date:
Thu, 6 Feb 2014 12:03:53 +0000
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Dear Colleagues,
 
At IBET we have been involved, together with CIRAD (Dr. Geneviève Libeau) in increasing the thermal stability of the current PPR vaccine. This started with the EU MARKVAC project and continued more recently with the frame of the VACNADA project from GALVMED.
 
A candidate formulation (Tris/Trehalose) for PPR vaccine using the Nig75/1 strain has been evaluated at IBET and transferred to one of the vaccine producing laboratories, NVI in Ethiopia (Dr. Martha Yami). All the collected results have showed that changing the vaccine formulation from the Weybridge medium to a Tris/Trehalose formulation increases the thermal stability of the current PPR vaccine, not only in a research laboratory context but also in a producing laboratory. The results obtained at NVI were presented in the second meeting of the Global PPR Research Alliance held in 2013 as a poster and are now accepted for publication in Vaccine. We agree that the use of a thermo-stable PPR vaccine will benefit in the eradication of this disease. We hope that our experience and knowledge could contribute to achieve that objective.
 
For more information, if someone is interested, we can send the pdfs of the related publications:
	* Silva AC, Yami M, Libeau G, Carrondo MJT. and Alves PM, “Evaluation of a new candidate formulation for Peste des Petits Ruminants in Ethiopia” (Vaccine 2014, in press). 
	* Silva AC, Carrondo MJ, Alves PM. Strategies for improved stability of Peste des Petits Ruminants Vaccine. Vaccine2011; 29(31): 4983-4991.
	* Silva AC, Delgado I, Sousa MF, Carrondo MJ, Alves PM. Scalable culture systems using different cell lines for the production of Peste des Petits Ruminants vaccine. Vaccine 2008; 26(26): 3305-3311.
	* Silva, A.C., Yami, M, Libeau, G., Carrondo, M.J.T. and Alves, P.M., “Testing a new formulation for Peste des Petits Ruminants Vaccine in Ethiopia”, (2013), Second meeting of the Global Peste de Petits Ruminants (PPR) Alliance, Nairobi, Kenya.
Best regards,
 
Manuel Carrondo

-- 
PS: Please acknowledge reception of this email
 
Manuel J T Carrondo, PhD
Professor of Chemical and Biochemical Engineering, FCT-UNL
Director, IBET
Apartado 12
2780-901 OEIRAS
PORTUGAL
EMAIL: [log in to unmask] PHONE: 351 21 4469362
FAX: 351 21 4421161 www.ibet.pt PA to Prof. Carrondo: Ana Margarida Machado
email: [log in to unmask] 

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