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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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"Establishment of a PPR Global Research and Expertise Network (PPR-GREN)" <[log in to unmask]>
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Wed, 5 Feb 2014 21:49:01 +0000
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satya parida <[log in to unmask]>
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satya parida <[log in to unmask]>
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To: Paul Rossiter <[log in to unmask]>
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Dear colleagues and friends,



I am leading a group at the Pirbright Institute, UK and started working with Dr Tom Barrett and Dr John Anderson on RP and PPR since early 2000. Currently I am working in 3 important areas,- development of PPR DIVA vaccine,- Immunological evaluation of new PPR vaccine in comparison to parent vaccine and Epidemiology of PPRV. These work closely related to reference laboratories at Pirbright, CIRAD and IVRI.





1.       Coordinating with 6 EU countries partners, 7 African countries and Turkey in an EU funded project we are mainly trying to learn a) the risk of transmission of PPRV from wildlife to susceptible animals and vice versa, mainly at the interface and b) the depth of epidemiology of PPRV by sequencing full genome of PPRV using NGS tools. This project also deals with the development of new diagnosis using non-invasive methods and d) one to one transmission (Project just started  two months before).



2.       Collaborating with AHVLA in a BBSRC/DFID project we have rescued Nigeria 75/1 vaccine virus that has given full protection upon challenge. At the moment we are investing the DIVA property of this vaccine after mutating the epitope of monoclonal antibody. Also we are trying to make this vaccine multivalent for other diseases.



3.       Collaborating with Indian partners from many premier Institutes in India, a new project from BBSRC-DBT that will start in May, 2014. In this grant we will a) rescue of Indian vaccine virus and virulent viruses from c-DNA copies, b) investigate the disease resistance in different species and breed by global gene sequencing and c) develop new diagnosis d) tracing the virus ( tagged virus)in the body of target animals to check the pathogenesis process of PPRV.



I hope these above studies will contribute to the PPR eradication programme. These work will be only successful with obtaining help from all of you. I will request to scientists from PPR endemic countries to send us virus/ infected tissues for whole genome sequencing to study the epidemiology of PPRV. The  transport cost will be met from the project and those scientist will be included in the publication.



Best regards

Satya



***********************************

Professor Satya Parida B.Vet,M.Vet,PhD

Head, Vaccine Differentiation Group at The Pirbright Institute

Adjunct Professor to Murdoch University, Australia,

Visiting Faculty at NIAB, India

Jenner Investigator , Oxford University, UK

Pirbright Institute, Pirbright, UK, GU24 0NF,

Email: [log in to unmask]<mailto:[log in to unmask]>,

Tel 0044 1483 231112/231020,

Fax 00441483 232448







From: Establishment of a PPR Global Research and Expertise Network (PPR-GREN) [mailto:[log in to unmask]] On Behalf Of Paul Rossiter

Sent: 30 January 2014 13:42

To: [log in to unmask]

Subject: PPR-GREN e-conference: Introduction to session one.





Dear Colleagues,

Welcome to the opening session of this e-conference.  Following the success of rinderpest eradication the international animal health community has identified peste des petits ruminants (PPR) as one of the possible new livestock disease for eradication. It is widely agreed that the basic technical tools and epidemiological understanding, which contributed to the eradication of rinderpest, already exist for PPR control and there is no reason why a progressive programme of global control of PPR cannot begin immediately.  Nevertheless, despite these tools and the lessons learned from rinderpest eradication, PPR continues to expand its global distribution and cause significant economic losses for many of the world’s poorest people.  The Joint OIE-FAO GF-TADs initiative has established a joint working group to promote progressive control of PPR. The working group recognizes the need for the global control strategy to be based upon a solid foundation of research and field experience and to share this innovative knowledge as widely and freely as possible. An internet –based forum to communicate with as many as possible of the people and organizations working on PPR is seen to be a potentially effective way to do this, and OIE and FAO will launch “The PPR Global Research and Experience Network” (PPR-GREN).

As stated in the invitation note, the overall purpose of this e- conference is to invite you to share your opinion and understanding gained from working with PPR to guide the formulation of PPR-GREN in a manner that will satisfy the needs of all stakeholders. It is anticipated that the network will prove a sustainable and popular medium for accelerating the uptake of new ideas and methodologies for PPR control.  It is important that the network should involve and appeal to those actors involved in the day to day control of PPR in the field as well as those working in research.

This first session aims to identify the key positive and negative factors influencing global, regional and national PPR control today and how these can either be built upon to advantage or resolved. It will benefit from your reports of success in PPR control and your advice on how this can be replicated elsewhere:  for instance; improved vaccination strategies that have brought about a sustainable reduction in disease incidence, disease surveillance that has facilitated better use of limited resources, imaginative use of the private animal health sector to implement both vaccination and disease reporting, etc. The conference is open to the most seemingly small and perhaps unremarkable operational changes that have improved control through, for example, better management of cold chains in difficult areas, increased participation of livestock owners in disease reporting, or identifying immunized and un-immunized herds and flocks.  These and other practical observations may be especially useful to other colleagues and the network proposes to share and propagate your ideas and innovations with them.

Equally importantly the conference needs to hear of the technical and operational difficulties you may be facing plus how you see these being resolved. Does it require fundamental research or operational change or might another participant to the conference already have the answer?   At the end of the first two weeks we hope to have widespread consensus of where efforts are being met with success and where there are major difficulties facing global progressive control allowing us to start to define the main areas requiring new techniques and new thinking. Needless to say, we do not expect this first PPR e-conference to solve every problem facing PPR control but it should allow us the opportunity to assess how effective internet interaction can be and how a PPR network might build on this.

After identifying these major areas of achievement and constraint the second and third sessions of the conference will attempt to prioritize specific technical and field implementation aspects of improved PPR control as themes and sub-themes for discussion and research within PPR-GREN; the fourth session will discuss what other preventable diseases of sheep and goats could be included for progressive control with PPR.     How the proposed PPR-GREN will actually operate and interact with all individual and group stakeholders in research, field and policy making roles will be discussed in the final week of the conference which will close on Friday March 7th. A summary report of the e-conference should be available in early April.

Please try to keep your contributions to the recommended maximum of 500-600 words (approximately 1 page), preferably less. If your contributions cover topics scheduled for a different session they will be held back until that session.   Contributions covering more than one session may be edited so that they can be read and discussed at the appropriate times. We have nearly 200 participants and at this early stage we do not all know each other. Therefore, please add your full name, title, address and affiliation (if any) to each correspondence, at least to begin  with, and if possible one or two lines stating your main interest and involvement in PPR control. (This will not be part of the 500 words).

We look forward to your contributions and to a thoughtful and productive conference.

Paul Rossiter - moderator.







St Michael's House,

EX17 4LA UK

Tel +44 (0)1363 866817



P.O.Box 30087 ,

GPO 00100 Nairobi.

Tel: +254 (0) 733 994456



Skype: paul,rossiter01



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