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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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From:
Emmanuel Albina <[log in to unmask]>
Reply To:
Emmanuel Albina <[log in to unmask]>
Date:
Mon, 3 Feb 2014 08:24:06 -0400
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Dear all,

I would also like to raise the issue of vaccine purity as quality 
requirements. As far as we are dealing with a live vaccine, extraneous 
agents (like ruminants pestivirus) should also be taken into account, 
either as potential direct pathogens introduced in the vaccine or as 
immunomodulators with side-effects on PPR immunization.

My advice would be to make a sanctuarized master vaccine seed stock 
somewhere and then secondary seed stocks in vaccine producers that will 
subsequently manage working stocks. The sanctuarizez stock should be 
carefully tested for extraneous agents, possibly by ultra-deep 
sequencing as we did recently on our Nigeria 75/1 vaccine stock.

All the best

Emmanuel


Le 31/01/2014 07:02, Peter Roeder a écrit :
> Dear Dr Afzal,
> It is good news to hear that the Pakistan authorities are planning a 
> PPR progressive control programme. I hope that you receive appropriate 
> funding to address the problem with sufficient intensity.
> My reason for responding to your message is that you have identified 
> two issues which are of major importance to PPR control both 
> nationally and globally. As was shown with rinderpest, vaccine quality 
> is an important matter to get right. Quality assurance of PPR vaccines 
> requires two exercises. Firstly, strict adherence to international 
> norms for vaccine production with specific SOPs for PPR vaccine 
> combined with stringent in-process controls. Secondly, on top of this, 
> ideally there should be an independent vaccine quality assurance 
> laboratory to examine vaccines post-production. This can be national, 
> provided that it is independent of the vaccine producer, or regional 
> as in the case of PANVAC.
> Your other point is also one that demands action. Maintaining adequate 
> cold chain in remote areas with little infrastructure is very 
> demanding and very expensive. It was a major constraint to rinderpest 
> control programmes initially. There are perhaps two ways that this can 
> be addressed. Firstly taking a One Health approach, about which we 
> hear so much these days, could involve sharing cold chain facilities 
> between human and animal vaccination programmes to cut costs and 
> favour maintenance of equipment. I believe that this was done 
> effectively in Southern Sudan in the 1990s. However, probably the most 
> beneficial development would be to get a quality-assured thermostable 
> formulation of attenuated vaccine on the market as quickly as 
> possible, as was done with rinderpest. Work at ILRI has progessed well 
> and I understand that the final stages of validation of an appropriate 
> PPR vaccine are in progress. To my mind this work should be promoted 
> and funded by all national and international agencies concerned to get 
> the process finished in a timely manner and to make a bank of vaccine 
> seed available for supply together with production SOPs and 
> training.In addition regional banking of quality-assured vaccines 
> could help to ensure adequate supplies.
> To my mind these must be considered as important components of any 
> global programme in support of national efforts.
> Best wishes
> Peter Roeder
>
> ***********************
> My contact details are:
> Prof Peter Roeder OBE, FRCVS, PhD, MSc, BVetMed
> Taurus Animal Health
> Hollyhedge Cottage
> Spats Lane
> Headley
> Hampshire GU35 8SY
> UK
> Tel:+441428717396 <tel:%2B441428717396>
> *******************************************


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