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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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rabindra singh <[log in to unmask]>
Wed, 5 Feb 2014 07:18:27 -0500
text/plain (9 kB) , text/html (19 kB)
Dear All,
At Indian Veterinary Research Institute we too have developed our Own Vaccine strain (using Indian isolate of Lineage-IV) vaccine virus and Indegenously Developed Monoclonal antibody based Diagnostic kits (both for PPR antigen and Anibody detection). These products are available commercially from the manufacturers.
Dr. R.P.Singh, 
Principal Scientist, Division of Biological Products,
Indian Veterinary Research Institute, Izatnagar, 
Bareilly-243 122 (Uttar Pradesh),
India

Alternate email: [log in to unmask]
Mobile:+91-9412360917
----- Original Message -----
From: Paul Rossiter
Sent: 02/05/14 01:06 PM
To: [log in to unmask]
Subject: From Dr Karim Tounkara, Director AU-PANVAC

This is the first contribution from The Pan African Veterinary Vaccine Centre of African Union (AU-PANVAC) and OIE Collaborating Centre in Quality Control of Veterinary Vaccines.

KEY POSITIVE FACTORS INFLUENCING GLOBAL, REGIONAL AND NATIONAL PPR CONTROL
Availability of Good Critical Control Tools: vaccine and diagnostics

a).Vaccines and their quality certification.

The currently used PPR vaccine is a safe, relatively easy and cheap to produce and confers life-long immunity after a single dose. Vaccination with this vaccine will ensure greater protection in vaccinated herds. Also, the availability of technologies for producing thermo stable or thermo-tolerant vaccines (even not fully validated by OIE) can assure that the problems associated with vaccine failures due to heat intolerance is greatly minimized.
The major vaccine producing laboratories have the skills to produce good quality PPR vaccines. The existence of an independent institution ensuring the quality of the produced PPR vaccine in Africa (The Pan African Veterinary Vaccine Centre of African Union AU-PANVAC and OIE Collaborating Centre in Quality Control of Veterinary Vaccines) is also a very important positive factor. 

b).Diagnostics.

The OIE recommended diagnostic assays/kits currently in use have proved to be adequate for PPR antigen (Immunocapture ELISA), antibodies (Competitive ELISA) and nucleic acid (RT-PCR and real-time PCR) detections and sequencing. The antibody detection assay is adequate for assessment of vaccination campaigns.

KEY NEGATIVE FACTORS INFLUENCING GLOBAL, REGIONAL AND NATIONAL PPR CONTROL

a) The PPR vaccine production capacity is grossly inadequate to meet the necessary quantity of PPR vaccine to undertake mass vaccination where needed.

b) The diagnostic reagents/kits currently available are relatively very expensive and not affordable by most countries. Even where affordable in some cases, accessibility is often a problem. 
 *ACTIONS TO BE UNDERTAKE TO ADDRESS THE IDENTIFIED PROBLEMS*
Concerted actions must be undertaken to validate the existing technologies for the production of thermo-stable PPR vaccine. 
AU-PANVAC Staff

Dr. Karim Tounkara
Director
Pan African Veterinary Vaccine Centre
African Union (AU/PANVAC)
P.O. Box 1746. DEBRE ZEIT - ETHIOPIA
Tel: + 251 11 437 12 86; + 251 11 433 80 01
Fax: + 251 11 433 88 44
Mobile: + 251 911 93 49 38

Date: Thu, 30 Jan 2014 13:42:16 +0000
From: [log in to unmask]
Subject: PPR-GREN e-conference: Introduction to session one.
To: [log in to unmask]

Dear Colleagues, 
Welcome to the opening session of this e-conference.Following the success of rinderpest eradication the international animal health community has identified peste des petits ruminants (PPR) as one of the possible new livestock disease for eradication. It is widely agreed that the basic technical tools and epidemiological understanding, which contributed to the eradication of rinderpest, already exist for PPR control and there is no reason why a progressive programme of global control of PPR cannot begin immediately.Nevertheless, despite these tools and the lessons learned from rinderpest eradication, PPR continues to expand its global distribution and cause significant economic losses for many of the world’s poorest people.The Joint OIE-FAO GF-TADs initiative has established a joint working group to promote progressive control of PPR. The working group recognizes the need for the global control strategy to be based upon a solid foundation of research and field experience and to share this innovative knowledge as widely and freely as possible. An internet –based forum to communicate with as many as possible of the people and organizations working on PPR is seen to be a potentially effective way to do this, and OIE and FAO will launch “The PPR Global Research and Experience Network” (PPR-GREN). 
As stated in the invitation note, the overall purpose of this e- conference is to invite you to share your opinion and understanding gained from working with PPR to guide the formulation of PPR-GREN in a manner that will satisfy the needs of all stakeholders. It is anticipated that the network will prove a sustainable and popular medium for accelerating the uptake of new ideas and methodologies for PPR control.It is important that the network should involve and appeal to those actors involved in the day to day control of PPR in the field as well as those working in research. 
This first session aims to identify the key positive and negative factors influencing global, regional and national PPR control today and how these can either be built upon to advantage or resolved. It will benefit from your reports of success in PPR control and your advice on how this can be replicated elsewhere:for instance; improved vaccination strategies that have brought about a sustainable reduction in disease incidence, disease surveillance that has facilitated better use of limited resources, imaginative use of the private animal health sector to implement both vaccination and disease reporting, etc. The conference is open to the most seemingly small and perhaps unremarkable operational changes that have improved control through, for example, better management of cold chains in difficult areas, increased participation of livestock owners in disease reporting, or identifying immunized and un-immunized herds and flocks.These and other practical observations may be especially useful to other colleagues and the network proposes to share and propagate your ideas and innovations with them. 
Equally importantly the conference needs to hear of the technical and operational difficulties you may be facing plus how you see these being resolved. Does it require fundamental research or operational change or might another participant to the conference already have the answer?At the end of the first two weeks we hope to have widespread consensus of where efforts are being met with success and where there are major difficulties facing global progressive control allowing us to start to define the main areas requiring new techniques and new thinking. Needless to say, we do not expect this first PPR e-conference to solve every problem facing PPR control but it should allow us the opportunity to assess how effective internet interaction can be and how a PPR network might build on this.
After identifying these major areas of achievement and constraint the second and third sessions of the conference will attempt to prioritize specific technical and field implementation aspects of improved PPR control as themes and sub-themes for discussion and research within PPR-GREN; the fourth session will discuss what other preventable diseases of sheep and goats could be included for progressive control with PPR.How the proposed PPR-GREN will actually operate and interact with all individual and group stakeholders in research, field and policy making roles will be discussed in the final week of the conference which will close on Friday March 7th. A summary report of the e-conference should be available in early April.
Please try to keep your contributions to the recommended maximum of 500-600 words (approximately 1 page), preferably less. If your contributions cover topics scheduled for a different session they will be held back until that session.Contributions covering more than one session may be edited so that they can be read and discussed at the appropriate times. We have nearly 200 participants and at this early stage we do not all know each other. Therefore, please add your full name, title, address and affiliation (if any) to each correspondence, at least to begin with, and if possible one or two lines stating your main interest and involvement in PPR control. (This will not be part of the 500 words).
We look forward to your contributions and to a thoughtful and productive conference. 
Paul Rossiter - moderator. 

St Michael's House,
EX17 4LA UK
Tel +44 (0)1363 866817

P.O.Box 30087 , 
GPO 00100 Nairobi.
Tel: +254 (0) 733 994456

Skype: paul,rossiter01

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