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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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From:
Paul Rossiter <[log in to unmask]>
Reply To:
Paul Rossiter <[log in to unmask]>
Date:
Thu, 6 Feb 2014 19:10:54 +0000
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Dear all,
 
It's a pleasure for me to join the forum. My name is Geneviève Libeau; an experience of more than 25 years in PPR diagnosis, thus having on my side a huge amount of anti-PPR antibodies, I am sure!!

Going through the last messages, I am convinced as said by Michael that:
 
- DIVA vaccines and companion diagnostic tests would be ideal tools for emergency vaccination in case of the occurrence of an outbreak in a PPR free country and would be the most realistic and cheapest measure than a stamping out policy leading to the destruction of large populations of animals. But for the moment the conventional vaccine does perfectly well if all reasonable care to ensure that have been taken. 

- Regarding combination of vaccines, the combination of capripox and PPR vaccines have been evaluated in sheep and goats and proved to be safe and immunogenic according to published information. Vaccines were either delivered from individually lyophilized preparation or delivered from a unique preparation containing each vaccine. Given alone or in combination at the recommended field dose, they conferred protection to homologous challenge. Thus in small scale experiments, it seems that there is no interference in the immunogenicity of each other but this need to be confirmed at large scale. Recombinant vaccines such as PPR-capripox vaccines exist as well. Here again in the domain of recombinant vaccines, research and validation should continue.
- Vaccine monitoring will be challenging even if the good tools are available: evaluate efficacy of vaccination, circulation of remaining field viruses as established during the rinderpest campaign. Therefore I would argue in favour of validated, standardised tools to gain in “real time” the right information. 

Best regards, 

Geneviève

(With the moderator's apology for the delay in posting this contribution).

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