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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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Sender: "Establishment of a PPR Global Research and Expertise Network (PPR-GREN)" <[log in to unmask]>
Date: Wed, 5 Feb 2014 12:03:25 +0000
Reply-To: Zelalem Tadesse <[log in to unmask]>
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From: Zelalem Tadesse <[log in to unmask]>
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Comments: To: "Kock, Richard" <[log in to unmask]>
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Dear All,

I concur with Richard that DIVA tests are crucial to determine prevalence as most countries have been undertaking extensive vaccination campaigns.

Thank you

Zelalem

Zelalem Tadesse (DVM, MSc, DLSHTM)

Epidemiologist | InterAfrican Bureau for Animal Resources - IBAR (Nairobi) | African Union Commission

Tel | +254-20-3674352 (Office); 071-8865692 (Cell)
E-mail: [log in to unmask]<mailto:[log in to unmask]> | Web: www.au-ibar.org<http://www.au-ibar.org/>
P.O.Box 30786, 00100 - Nairobi | Kenya


From: Establishment of a PPR Global Research and Expertise Network (PPR-GREN) [mailto:[log in to unmask]] On Behalf Of Kock, Richard
Sent: Wednesday, February 05, 2014 2:19 PM
To: [log in to unmask]
Subject: Re: PPR-GREN e-conference: Introduction to session one.

Thanks Muhammad (and others)

Your mention of Asian buffalo as a possible host is consistent with our findings in Africa, where antibody footprints in African buffalo exist, in many ecosystems but we know little about their ability to circulate virus within their populations and therefore ability to act as true hosts and not just spill over hosts and vectors.

The forum has suggested that baselines are important. Well said but I am not sure how we can achieve a baseline given the high levels of vaccination already implemented in many countries and reluctance of governments to spend money to obtain baselines until the disease is already present (!) and this is then compounded by no practical available tests to differentiate between vaccine and field virus antibody production? I note that Zambia recently published a risk assessment for PPR and it was high. I think this is rather stating the obvious but if this was a necessary step to action all well and good. Again wildlife (buffalo and others) can be useful sentinels in this respect and perhaps even cattle will help to determine cryptic foci of infection but DIVA tests might also be of value as discussed often in the past. I am afraid that we may have a bit of a spaghetti to unravel with PPR now....and FAO and other regional bodies have a major task to get the whole community working to common aims and objectives and in a coordinated manner. This forum can help this process.

Sincerely

Richard

From: Muhammad Abubakar [mailto:[log in to unmask]]
Sent: 05 February 2014 09:50
To: Kock, Richard
Cc: [log in to unmask]<mailto:[log in to unmask]>
Subject: Re: PPR-GREN e-conference: Introduction to session one.

Dear Prof Kock
Good to see you comments.

I was also of the view of such variation in disease severity in-spite of vaccination campaigns. As you might seen comments from one Indian colleague on the characterization of PPRV from an outbreak which is not similar with the lineage IV and was confirmed using non conventional methods which is also interesting.
It is good to know that you are going to run a project on wildlife role. Let me tell you that we have already started such an activity in Pakistan. We have discovered the serological evidence of sero-conversion of PPRV antibodies in companion animals including buffaloes.

Hope to be in touch on this...

Regards



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