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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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Sender: "Establishment of a PPR Global Research and Expertise Network (PPR-GREN)" <[log in to unmask]>
Date: Tue, 4 Feb 2014 08:24:34 +0300
Reply-To: "THOMAS D. DULU" <[log in to unmask]>
Message-ID: <[log in to unmask]>
From: "THOMAS D. DULU" <[log in to unmask]>
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Comments: To: Emmanuel Albina <[log in to unmask]>
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Dear All,

I am elated to get a chance to contribute to the forum.

There is an urgent need to develop a winner Regional PPR disease control
strategy.

PPR is a transboundary disease and its control is anchored to
implementation of a harmonized regional strategy.

What worked during the Rinderpest eradication campaign should be replicated.

1. Development of thermostable vaccine which will address cold chain
challenges that face delivery of vaccine.

2. Undertake two rounds of mass vaccination.

3. Elaborate pre- and post - vaccination survey to ensure protective
sero-conversion.

4. Epidemiologists have to get together to harmonized epidemiological
framework and roadmap for the global control and eradication of PPR.

5. Marshal political will to spearhead awareness creation, publicity and
resource mobilization.

yours sincerely,



 

*Dr Thomas Daido Dulu*
Deputy Director of Veterinary Services,
State Department of Livestock, Ministry of Agriculture, Livestock and
Fisheries
P.O. Private Bag Kabete, Kangemi Post Code 00625,
NAIROBI, KENYA.
Tel: +254 721 276 508
       +254 789 656 295


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On Mon, Feb 3, 2014 at 3:24 PM, Emmanuel Albina <
[log in to unmask]> wrote:

>  Dear all,
>
> I would also like to raise the issue of vaccine purity as quality
> requirements. As far as we are dealing with a live vaccine, extraneous
> agents (like ruminants pestivirus) should also be taken into account,
> either as potential direct pathogens introduced in the vaccine or as
> immunomodulators with side-effects on PPR immunization.
>
> My advice would be to make a sanctuarized master vaccine seed stock
> somewhere and then secondary seed stocks in vaccine producers that will
> subsequently manage working stocks. The sanctuarizez stock should be
> carefully tested for extraneous agents, possibly by ultra-deep sequencing
> as we did recently on our Nigeria 75/1 vaccine stock.
>
> All the best
>
> Emmanuel
>
>
> Le 31/01/2014 07:02, Peter Roeder a écrit :
>
>    Dear Dr Afzal,
>  It is good news to hear that the Pakistan authorities are planning a PPR
> progressive control programme. I hope that you receive appropriate funding
> to address the problem with sufficient intensity.
>  My reason for responding to your message is that you have identified two
> issues which are of major importance to PPR control both nationally and
> globally. As was shown with rinderpest, vaccine quality is an important
> matter to get right. Quality assurance of PPR vaccines requires two
> exercises. Firstly, strict adherence to international norms for vaccine
> production with specific SOPs for PPR vaccine combined with stringent
> in-process controls. Secondly, on top of this, ideally there should be an
> independent vaccine quality assurance laboratory to examine vaccines
> post-production. This can be national, provided that it is independent of
> the vaccine producer, or regional as in the case of PANVAC.
>  Your other point is also one that demands action. Maintaining adequate
> cold chain in remote areas with little infrastructure is very demanding and
> very expensive. It was a major constraint to rinderpest control programmes
> initially. There are perhaps two ways that this can be addressed. Firstly
> taking a One Health approach, about which we hear so much these days, could
> involve sharing cold chain facilities between human and animal vaccination
> programmes to cut costs and favour maintenance of equipment. I believe that
> this was done effectively in Southern Sudan in the 1990s. However, probably
> the most beneficial development would be to get a quality-assured
> thermostable formulation of attenuated vaccine on the market as quickly as
> possible, as was done with rinderpest. Work at ILRI has progessed well and
> I understand that the final stages of validation of an appropriate PPR
> vaccine are in progress. To my mind this work should be promoted and funded
> by all national and international agencies concerned to get the process
> finished in a timely manner and to make a bank of vaccine seed available
> for supply together with production SOPs and training.In addition regional
> banking of quality-assured vaccines could help to ensure adequate supplies.
>  To my mind these must be considered as important components of any global
> programme in support of national efforts.
>  Best wishes
> Peter Roeder
>
> ***********************
> My contact details are:
> Prof Peter Roeder OBE, FRCVS, PhD, MSc, BVetMed
> Taurus Animal Health
> Hollyhedge Cottage
> Spats Lane
> Headley
> Hampshire GU35 8SY
> UK
> Tel:+441428717396
> *******************************************
>
>
>
> ------------------------------
>
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