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Establishment of a PPR Global Research and Expertise Network (PPR-GREN)

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Sender: "Establishment of a PPR Global Research and Expertise Network (PPR-GREN)" <[log in to unmask]>
Date: Wed, 5 Feb 2014 06:40:38 +0000
Reply-To: Niwael Mtui <[log in to unmask]>
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From: Niwael Mtui <[log in to unmask]>
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Dear  all,
I thank the GF TADs PPR Working Group for this initiative, this is fitting
well in this era of advanced information technology.
I want to share with you about what we have been doing so far in
controlling the disease. 
PPR cases were severely reduced after vaccinations were carried out
covering at least 80% coverage of the population at risk accompanied by pre and
post vaccination sero and clinical surveillance to inform of the success of the
vaccination. From what we experienced a second round of vaccination within a
year is important. The need to plan for active surveillance was very evident,
PPR appeared in villages where disease had not been reported and it took time
realizes that they have been hit by an emerging disease. 
Yes we need to create awareness on the negative impact of the disease in
terms of food security and socio economy of rural households so that more
resources could be allocated at national budgets for PPR control. PPR vaccine itself
is cheap however the process of delivering to the animal is what makes
vaccination campaigns expensive. Challenges regarding handling of the vaccines exist
and formulation of heat stable vaccine will be very welcome idea as well as a
DIVA vaccine to differentiate vaccinated from infected ones. 
There are unknowns. As others have pointed out what is the role of
other ruminants (wild and domestic) in the maintenance of the disease. 
All in all the a need for a legislation directing systematic
approaches in the control/prevention of the disease is critical.
 
Best regards,


Niwael J. Mtui-Malamsha


“If your dreams do not scare you, they are not big enough” by President Ellen Johnson Sirleaf



On Tuesday, 4 February 2014, 16:03, THOMAS D. DULU <[log in to unmask]> wrote:
 
Dear All,

I am elated to get a chance to contribute to the forum.

There is an urgent need to develop a winner Regional PPR disease control strategy.

PPR is a transboundary disease and its control is anchored to implementation of a harmonized regional strategy.

What worked during the Rinderpest eradication campaign should be replicated.

1. Development of thermostable vaccine which will address cold chain challenges that face delivery of vaccine.

2. Undertake two rounds of mass vaccination.

3. Elaborate pre- and post - vaccination survey to ensure protective sero-conversion.

4. Epidemiologists have to get together to harmonized epidemiological framework and roadmap for the global control and eradication of PPR.

5. Marshal political will to spearhead awareness creation, publicity and resource mobilization.

yours sincerely,



 


Dr Thomas Daido Dulu
Deputy Director of Veterinary Services,
State Department of Livestock, Ministry of Agriculture, Livestock and Fisheries
P.O. Private Bag Kabete, Kangemi Post Code 00625,
NAIROBI, KENYA.
Tel: +254 721 276 508
       +254 789 656 295
 
 DISCLAIMER: 

The information  contained in or accompanying  this e-mail  is intended  for the use of the stated  recipient  only. It may contain  confidential,  proprietary  or legally  privileged  information. No confidentiality or privilege is waived or  lost by any  mistransmission. If you receive  this message  in error, please immediately delete it and  all copies  of it from your  system, destroy  any hard copies  of it and notify Dulu Thomas Daido. You must not, directly  or indirectly,  use, disclose,  distribute,  print, or copy  any part of  this message  if you are not  the intended  recipient.


On Mon, Feb 3, 2014 at 3:24 PM, Emmanuel Albina <[log in to unmask]> wrote:

Dear all,
>
>I would also like to raise the issue of vaccine purity as quality
    requirements. As far as we are dealing with a live vaccine,
    extraneous agents (like ruminants pestivirus) should also be taken
    into account, either as potential direct pathogens introduced in the
    vaccine or as immunomodulators with side-effects on PPR
    immunization.
>
>My advice would be to make a sanctuarized master vaccine seed stock
    somewhere and then secondary seed stocks in vaccine producers that
    will subsequently manage working stocks. The sanctuarizez stock
    should be carefully tested for extraneous agents, possibly by
    ultra-deep sequencing as we did recently on our Nigeria 75/1 vaccine
    stock.
>
>All the best
>
>Emmanuel
>
>
>
>Le 31/01/2014 07:02, Peter Roeder a écrit :
>
>Dear Dr Afzal,
>>
It is good news to hear that the Pakistan authorities are planning a PPR progressive control programme. I hope that you receive appropriate funding to address the problem with sufficient intensity.
>>
My reason for responding to your message is that you have identified two issues which are of major importance to PPR control both nationally and globally. As was shown with rinderpest, vaccine quality is an important matter to get right. Quality assurance of PPR vaccines requires two exercises. Firstly, strict adherence to international norms for vaccine production with specific SOPs for PPR vaccine combined with stringent in-process controls. Secondly, on top of this, ideally there should be an independent vaccine quality assurance laboratory to examine vaccines post-production. This can be national, provided that it is independent of the vaccine producer, or regional as in the case of PANVAC. 
>>
Your other point is also one that demands action. Maintaining adequate cold chain in remote areas with little infrastructure is very demanding and very expensive. It was a major constraint to rinderpest control programmes initially. There are perhaps two ways that this can be addressed. Firstly taking a One Health approach, about which we hear so much these days, could involve sharing cold chain facilities between human and animal vaccination programmes to cut costs and favour maintenance of equipment. I believe that this was done effectively in Southern Sudan in the 1990s. However, probably the most beneficial development would be to get a quality-assured thermostable formulation of attenuated vaccine on the market as quickly as possible, as was done with rinderpest. Work at ILRI has progessed well and I understand that the final stages of validation of an appropriate PPR vaccine are in progress. To my mind this work should be promoted and funded by all
 national and international agencies concerned to get the process finished in a timely manner and to make a bank of vaccine seed available for supply together with production SOPs and training.In addition regional banking of quality-assured vaccines could help to ensure adequate supplies. 
>>
To my mind these must be considered as important components of any global programme in support of national efforts.
>>
Best wishes
>>Peter Roeder
>>
>>***********************
>>
>>My contact details are: 
>>Prof Peter Roeder OBE, FRCVS, PhD, MSc, BVetMed
>>Taurus Animal Health 
>>Hollyhedge Cottage 
>>Spats Lane 
>>Headley 
>>Hampshire GU35 8SY
>>UK 
>>Tel:+441428717396
>>*******************************************
>
>
>
>>________________________________
> 
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