Dear Subscribers,
There was a recent paper entitled “Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh” published on Journal of Virology, volumes 450–451, February 2014, Pages 297–307. Abstract and link to the original article are provided and hope this article is of interest to you.
ABSTRACT: In Bangladesh, little is known about the genomic composition and antigenicity of highly pathogenic avian influenza A(H5N1) viruses, their geographic distribution, temporal patterns, or gene flow within the avian host population. Forty highly pathogenic avian influenza A(H5N1) viruses isolated from humans and poultry in Bangladesh between 2008 and 2012 were analyzed by full genome sequencing and antigenic characterization. The analysis included viruses collected from avian hosts and environmental sampling in live bird markets, backyard poultry flocks, outbreak investigations in wild birds or poultry and from three human cases. Phylogenetic analysis indicated that the ancestors of these viruses reassorted (1) with other gene lineages of the same clade, (2) between different clades and (3) with low pathogenicity avian influenza A virus subtypes. Bayesian estimates of the time of most recent common ancestry, combined with geographic information, provided evidence of probable routes and timelines of virus spread into and out of Bangladesh.
AUTHORS: Nancy A. Gerloffa, Salah Uddin Khanb, Amanda Balisha, Ireen S. Shantab, Natosha Simpsona, LaShondra Bermana, Najmul Haiderb, Mee Kian Poha, Ausraful Islamb, Emily Gurleyb, Md. Abdul Hasnatb, T. Deyc, Bo Shua, Shannon Emerya, Stephen Lindstroma, Ainul Haqued, Alexander Klimova, 1, Julie Villanuevaa, Mahmudur Rahmane, Eduardo Azziz-Baumgartnera, Md Ziaur Rahmanb, Stephen P. Lubyb, Nord Zeidnerb, Ruben O. Donisa, Katharine Sturm-Ramirezb, C. Todd Davisa
http://www.sciencedirect.com/science/article/pii/S0042682213006867
Sincerely yours,
TADs-Network-Asia
Emergency Center for Transboundary Animal Diseases (ECTAD)
FAO Regional Office for Asia and the Pacific (FAORAP)
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Bangkok, 10200, Thailand
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